Research output per year
Research output per year
Personal profile
Research interests
Dr. Denis O Shea holds a BSc (Hons) Chemistry from the National University of Ireland, Maynooth and having completed a study into the design and synthesis of novel chemotherapeutic compounds [within the Inorganic Pharmaceutical and Biomimetic Research Group under the supervision of Dr. Michael Devereux] was awarded his PhD from Dublin Institute of Technology. He joined the School of Food Science and Environmental Health as a lecturer in Chemistry and Pharmaceutical analysis in 2000.
Professional Information
The synthesis and characterisation of novel transition metal based complexes and investigation of their antimicrobial, anti-cancer and catalytic/biomimetic activity, Design of quantitative techniques for the measurement of metal ion absorption by fungal s
Education/Academic qualification
PhD
Award Date: 1 Jan 2004
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Collaborations and top research areas from the last five years
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Enhanced pyrazolopyrimidinones cytotoxicity against glioblastoma cells activated by ROS-Generating cold atmospheric plasma
He, Z., Charleton, C., Devine, R. W., Kelada, M., Walsh, J. M. D., Conway, G. E., Gunes, S., Mondala, J. R. M., Tian, F., Tiwari, B., Kinsella, G. K., Malone, R., O'Shea, D., Devereux, M., Wang, W., Cullen, P. J., Stephens, J. C. & Curtin, J. F., 15 Nov 2021, In: European Journal of Medicinal Chemistry. 224, 113736.Research output: Contribution to journal › Article › peer-review
Open Access -
Influence of molecular weight fractionation on the antimicrobial and anticancer properties of a fucoidan rich-extract from the macroalgae Fucus vesiculosus
Cabral, E. M., Mondala, J. R. M., Oliveira, M., Przyborska, J., Fitzpatrick, S., Rai, D. K., Sivagnanam, S. P., Garcia-Vaquero, M., O'Shea, D., Devereux, M., Tiwari, B. K. & Curtin, J., 1 Sep 2021, In: International Journal of Biological Macromolecules. 186, p. 994-1002 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Synergistic Cytotoxicity Between Cold Atmospheric Plasma and Pyrazolopyrimidinones Against Glioblastoma Cells
He, Z., Charleton, C., Devine, R., Kelada, M., Walsh, J. M. D., Conway, G., Gunes, S., Mondala, J. R. M., Tian, F., Tiwari, B., Kinsella, G. K., Malone, R., O'Shea, D., Devereux, M., Wang, W., Cullen, P. J., Stephens, J. C. & Curtin, J. F., 4 Feb 2021, 26 p.Research output: Other contribution
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Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity
Thornton, L., Dixit, V., Assad, L. O. N., Ribeiro, T. P., Queiroz, D. D., Kellett, A., Casey, A., Colleran, J., Pereira, M. D., Rochford, G., McCann, M., O'Shea, D., Dempsey, R., McClean, S., Kia, A. F. A., Walsh, M., Creaven, B., Howe, O. & Devereux, M., Jun 2016, In: Journal of Inorganic Biochemistry. 159, p. 120-132 13 p.Research output: Contribution to journal › Article › peer-review
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Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic potential with fast acting in vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines
O'Connor, M., Kellett, A., McCann, M., Rosair, G., McNamara, M., Howe, O., Creaven, B. S., McClean, S., Foltyn-Arfa Kia, A., O'Shea, D. & Devereux, M., 8 Mar 2012, In: Journal of Medicinal Chemistry. 55, 5, p. 1957-1968 12 p.Research output: Contribution to journal › Article › peer-review